CYR61 (cysteine-rich, angiogenic inducer, 61)
نویسندگان
چکیده
منابع مشابه
Integration of Cysteine-rich angiogenic inducer 61 (CYR61) into collagen biomaterial promotes the therapeutic potential of circulating angiogenic cells
108 ©2013 Society For Biomaterials
متن کاملAtlas of Genetics and Cytogenetics in Oncology and Haematology CYR 61 ( cysteine - rich , angiogenic inducer , 61 )
Other names: CCN1, GIG1, IGFBP10 HGNC (Hugo): CYR61 Location: 1p22.3 Note CYR61 (cysteine-rich angiogenic inducer 61; also named CCN1), first identified as a serum-inducible immediate-early gene, encodes a secreted, extracellular matrix-associated protein that regulates diverse cellular functions (Lau, 2011). CYR61 and five later identified homologs comprise the six-member CCN family, named aft...
متن کاملRole of cysteine-rich angiogenic inducer 61 in fibroblast-like synovial cell proliferation and invasion in rheumatoid arthritis
Cysteine‑rich angiogenic inducer 61 (Cyr61) is a novel molecule that has been shown to be increased in the synovial tissues of patients with rheumatoid arthritis (RA). The present study was conducted in order to investigate the role of Cyr61 in the pathogenesis of RA. A human genome‑wide gene assay was used to screen gene expression in synovial tissues obtained from four patients with RA and th...
متن کاملCysteine-rich 61 (Cyr61) upregulated in pulmonary arterial hypertension promotes the proliferation of pulmonary artery smooth muscle cells
Background: We aimed to evaluate the expression of cysteine rich 61 (Cyr61) in patients with pulmonary arterial hypertension (PAH) as well as monocrotaline (MCT) induced PAH rat, and further investigate the effects and potential mechanisms of Cyr61 on the proliferation of pulmonary arterial smooth muscle cells (PASMCs). Methods and Results: Plasma samples were collected from 20 patients with id...
متن کاملThe matricellular protein cysteine-rich protein 61 (CCN1/Cyr61) enhances physiological adaptation of retinal vessels and reduces pathological neovascularization associated with ischemic retinopathy.
Retinal vascular damages are the cardinal hallmarks of retinopathy of prematurity (ROP), a leading cause of vision impairment and blindness in childhood. Both angiogenesis and vasculogenesis are disrupted in the hyperoxia-induced vaso-obliteration phase, and recapitulated, although aberrantly, in the subsequent ischemia-induced neovessel formation phase of ROP. Yet, whereas the histopathologica...
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ژورنال
عنوان ژورنال: Atlas of Genetics and Cytogenetics in Oncology and Haematology
سال: 2013
ISSN: 1768-3262
DOI: 10.4267/2042/51039